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Related post: acquisition of a major portion of the enteric disease program.
Approximate Level of Support
Activity Number Amount
Infectious Disease Epidemiology
Research Contracts 2 182,948
Research Grants 3 429,631
Fellowships 1 16,118
Research Contracts 6 749,029
Research Grants 23 1,502,707
Program Projects 1 432,744
Fellowships 3 45,932
Training Grants 1 36,504
Totals 40 3,395,613
Epidemiologic and Biometric Consultation
In the area of data monitoring for clinical trials, Dr. William Blackwelder
assisted contractors studying abbreviated courses of therapy of amphotericin
B and 5-fluorcytosine for cryptococcal meningitis, efficacy of prophylactic
penicillin for neonatal infections with group B Streptococcus , and efficacy
of antiviral treatment of herpes labial is. As the Institute supports more
collaborative clinical trials, these activities will grow as statistical
advice is more frequently required in both study design and data monitoring.
Dr. Blackwelder concluded the development of methods to facilitate more
precise calculation of pneumococcal antibody determined by Tentex Forte Price In India RIA in the
laboratory of Dr. Gerald Schiffman. The Branch staff provided statistical
consultation to investigators studying pneumococcal vaccine in otitis media
and lupus erthyematosus , assisted in managing a large volume of epidemiologic
and clinical data generated by one enteric disease center, collaborated with
Dr.^David Ailing, LCI, NIAID and Sir Charles Stuart-Harris, Fogarty Scholar,
in analyzing national Tentex Forte Tablet influenza and pneumonia data to refine epidemiological
association of increased mortality rates and major activity of influenza in
the U.S., and assisted investigators at the Walter Reed Army Institute of
Research in designing a multi center study to determine the value of an IgE
standard developed by the lAIDP and in analyzing the resulting data.
Members of the Branch Staff participated Tentex Forte Himalaya in many trans-NIH and Non-NIH
committees. Dr. Blackwelder was active in a research advisory group which
was convened by the Cystic Fibrosis Foundation and charged with developing
a protocol for a multi center clinical trial which might be sponsored by the
agency. Dr. Curl in represented the Institute in the Digestive Disease
Coordinating Committee and Dr. Kaslow functioned as the Institute's
representative to the NIH and PHS Diabetes Committees. Dr. Curl in and
Dr. Kaslow both were active in the NIH Epidemiology Committee.
Dr. Richard A. Kaslow, research epidemiologist in the Branch, instituted a
collaborative field study of Lyme disease in Wisconsin with Dr. Jeffrey
Davis, Wisconsin Department of Health, and Dr. Andrew Spielman, Harvard
University School of Public Health. Initial findings suggest the disease
is underreported and is localized in areas in which the supected tick
vector is found. An effort was begun to increase physician awareness to
detect additional cases so definitive epidemiologic studies can be initiated.
Epidemiologists in the Branch initiated with Dr. Daniel Mull ally of the
Asthma and Allergic Disease Branch, lAIDP, and Dr. William Howard of the
Children's Hospital National Medical Center a 20 year retrospective analysis
of admissions to the Hospital for asthma. A thorough methodological review
was undertaken first to document the increase in asthma admissions suggested
by Dr. Howard's preliminary tabulations and then to search for factors that
could account for the increase.
HLA and Epidemiology
A collaborative study of lupus erythematosus in black Americans was initiated
with the scientists of the NCI and investigators at the Johns Hopkins
School of Medicine. A questionnaire developed by Dr. Kaslow and Dr. Jill B.
Schiff will be administered to cases and carefully selected controls to Himalaya Tentex Forte seek
possible environmental risk factors, and the HLA type of both cases and
controls will be determined. This study seeks to develop an epidemiologic
methodology in addition to identifying HLA associations with this disease in
the black population. Dr. Kaslow and colleagues at the CDC and Stanford
University prepared to expand epidemiologic studies in victims of common
source enteric disease epidemics, to define further the extent to which Reiter's
syndrome is associated with specific bacterial agents, and to identify immuno-
genetic charateri Tentex Forte Tablets sties that regulate development of this Buy Tentex Forte immunologic disease.
Dr. Kaslow' s previous work at the CDC identified probable Reiter's syndrome
among patients affected in Shigella flexneri epidemics but failed to identify
Reiter's syndrome among patients of Shigella sonnei outbreaks. Pursuit of
these observations may identify specific bacterial antigens which trigger
the pathologic immune response in patients with the HLA-B27 phenotype.
Field work began on the contract to Johns Hopkins University to note the
influence of HLA in the immune response to viral vaccines in humans. Inter-
views were conducted and baseline sera were obtained in the Amish population.
Children of all ages from a large proportion of families studied were found
to be sero-negative to rubella. Thus, it will be quite feasible to enroll
a sufficient number of volunteers to conduct the Tentex Forte Price study. The Amish population
will benefit more than anticipated from the vaccinations offered by the study.
Epidemiology of Nosocomial Infections
Support for the CDC SENIC project concluded, and a grant to study the epidemi-
ology of nosocomial infections was awarded to the Rhode Island Department of
Health. This ambitious effort, which utilizes a sample of patients drawn
from all general hospitals in the state, will identify host factors modifying
efficacy of infection control programs.
Enteric Diseases Centers
The initial three-year phase was completed at the three incumbent Infectious
Enteric Disease Study Centers. Many of the findings which were previewed in
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